Publications

Prediction of brain age using structural magnetic resonance imaging: A comparison of clinical validity of publicly available software packages
Predicting brain age from structural magnetic resonance images is commonly used as a biomarker of biological aging and brain health. …
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Single-dose rapamycin increases brain glucose metabolism but reduces synaptic density in Long-Evans rats: A PET imaging study
Rapamycin, an inhibitor of the mechanistic target of rapamycin (mTOR), has shown promise as a neuroprotective compound in preclinical …
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In Vivo Medical Imaging for Assessing Geroprotective Interventions in Humans
There is a growing interest in developing drugs with a general geroprotective effect, aimed at slowing down aging. Several compounds …
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Multimodal Brain Age Prediction Using Machine Learning: Combining Structural MRI and 5-HT2AR PET-derived Features
To better assess the pathology of neurodegenerative disorders and the efficacy of neuroprotective interventions, it is necessary to …
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Evaluating the effect of rapamycin treatment in Alzheimer’s disease and aging using in vivo imaging: the ERAP phase IIa clinical study protocol
Rapamycin is an inhibitor of the mechanistic target of rapamycin (mTOR) protein kinase, and preclinical data demonstrate that it is a …
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Prediction of brain age using structural magnetic resonance imaging: A comparison of accuracy and test–retest reliability of publicly available software packages
Brain age prediction algorithms using structural magnetic resonance imaging (MRI) aim to assess the biological age of the human brain. …
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